Current management of hepatocellular carcinoma

doi:10.3748/wjg.v20.i30.10223

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2014; 20(30): 10223-10237
Published online Aug 14, 2014. doi: 10.3748/wjg.v20.i30.10223

Table 10 Ongoing and reported randomized phase II-III trials in the treatment of advanced hepatocellular carcinoma

Treatment	Acronym	Treatment	Primary outcome
First line treatment	¹SEARCH	Erlotinib + Sorafenib vs Sorafenib	OS
	¹BRISK-FL	Brivanib vs Sorafenib	OS
	-	Linifanib vs Sorafenib	OS
Second line treatment	¹EVOLVE-1	Everolimus vs Placebo	OS
	¹BRISK	Brivanib vs Placebo	OS
	¹BRISK-APS	Brivanib vs Placebo	OS
	Toh et al[158] 2010	Linifanib	OS: 9.7 mo
Phase 2 trial (reported)	Hsu et al[159] 2010	Sorafenib + Tegafur/Uracil	OS: 7.4 mo
	Thomas et al[160] 2007	Erlotinib	OS: 6.25 mo
	Thomas et al[161] 2009	Erlotinib + Bevacizumab	OS: 15.7 mo
	Faivre et al[162] 2009	Sunitinib	OS: 8 mo

¹ClinicalTrials.gov. Available at: http://www.clinicaltrials.gov/. OS: Overall survival.

Citation: Tabrizian P, Roayaie S, Schwartz ME. Current management of hepatocellular carcinoma. World J Gastroenterol 2014; 20(30): 10223-10237
URL: https://www.wjgnet.com/1007-9327/full/v20/i30/10223.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i30.10223