Helicobacter pylori gamma-glutamyl transpeptidase and its pathogenic role

doi:10.3748/wjg.v20.i3.630

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2014; 20(3): 630-638
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.630

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Figure 3 Effects of Helicobacter pylori gamma-glutamyl transpeptidase on T cell-mediated immunity. Helicobacter pylori gamma-glutamyl transpeptidase (GGT) and VacA inhibit T cell proliferation and differentiation to T helper 1 (T_H1) and T_H17. They also prevent T cell immunity by reprogramming dendritic cells to produce interleukin-10 (IL-10) and IL-18 and promote the differentiation of naive T cells into T regulatory (Treg) cells that further suppress T_H1 and T_H17 effector functions. FOXP3: Forkhead box P3; NFAT: Nuclear factor of activated T cells; IFN-γ: Interferon gamma.

Citation: Ricci V, Giannouli M, Romano M, Zarrilli R. Helicobacter pylori gamma-glutamyl transpeptidase and its pathogenic role. World J Gastroenterol 2014; 20(3): 630-638
URL: https://www.wjgnet.com/1007-9327/full/v20/i3/630.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i3.630