Epidermal growth factor upregulates Skp2/Cks1 and p27kip1 in human extrahepatic cholangiocarcinoma cells

doi:10.3748/wjg.v20.i3.755

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2014; 20(3): 755-773
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.755

Table 2 Independent and significant prognostic factors for patients with extrahepatic cholangiocarcinoma

Parameters	Category	OR	95%CI	P value
Age	> 65 yr	2.707	1.341-5.464	< 0.01
AJCC stage	IA
	IB	2.543	0.695-9.306	0.159
	IIA	0.801	0.185-3.477	0.767
	IIB	3.534	1.041-11.997	0.043
	III	16.446	1.370-197.470	0.027
	IV	92.965	5.585-1547.531	< 0.010
Histologic type	Well-differentiated
	Moderately-differentiated	6.041	2.146-17.006	< 0.010
	Poorly-differentiated	5.620	1.586-19.917	< 0.010
Immunostaining intensity of Skp2	0
	1	1.308	0.571-2.994	0.526
	2	3.782	1.581-9.051	< 0.010
	3	2.312	1.127-6.941	0.048

AJCC: American Joint Commission on Cancer; Skp2: S-phase kinase-associated protein 2.

Citation: Kim JY, Kim HJ, Park JH, Park DI, Cho YK, Sohn CI, Jeon WK, Kim BI, Kim DH, Chae SW, Sohn JH. Epidermal growth factor upregulates Skp2/Cks1 and p27^kip1 in human extrahepatic cholangiocarcinoma cells. World J Gastroenterol 2014; 20(3): 755-773
URL: https://www.wjgnet.com/1007-9327/full/v20/i3/755.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i3.755