Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

Figure 3 Methotrexate-induced structural damage to hepatic tissues in rats treated with antioxidant agents. A: Photomicrographs of representative H-E stained liver tissues are shown at × 40; B:The MTX + NAC group showed radial hepatocytes in the region from the central vein to the periphery; C: The MTX + AMF group showed sinusoidal dilatation (arrows) that was similar to that observed in the untreated model group. VC: Vena centralis; H-E: Hematoxylin-eosin; MTX: Methotrexate; NAC: N-acetyl cysteine; AMF: Amifostine.