RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 and cis-diamminedichloroplatinum on gastric cancer

Figure 6 PCI-24781 synergized with the chemotherapeutic effect of cis-diamminedichloroplatinum in a xenograft model. A, B: Tumor growth curves showed a significant difference between the PCI-24781- or cis-diamminedichloroplatinum (CDDP)-treated mice and the negative control. PCI-24781 or CDDP also dramatically decreased the tumor weight. The combination treatment obtained the smallest and lightest tumors compared to the single treatment or negative control groups. Immunohistochemical analysis of the GC xenograft specimens demonstrated the significantly decreased tumor proliferation (C, D; PCNA positive) and increased apoptosis (E, F; TUNEL positive) in the PCI-24781- or CDDP-treated tumors, with a synergistic effect in the combination treatment. CDDP: Cis-diamminedichloroplatinum; Combo: Combination treatment. ^aP < 0.05 vs the control; ^cP < 0.05 vs PCI-24781 or CDDP. Bar = 10 μm.