Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells

Figure 9 The effect of aspirin on proteins involved in cell cycle progression in neuroendocrine BON1 and NCI-H727 tumor cells. Human pancreatic neuroendocrine BON1 (A) and human bronchopulmonary NCI-H727 (B) cells were treated with the indicated concentrations of aspirin for 24 and 48 h. The expression of p21, CDK4, p53, cyclin D3 and a β-actin loading control was subsequently evaluated by Western blot analysis. A representative blot from 3 independently performed experiments is shown.