Helicobacter pylori and oral pathology: Relationship with the gastric infection

Table 3 Helicobacter pylori detection in aphthous stomatitis n (%)

Ref.	Sample (study design)	Diagnostic method	Patient profile	H. pylori detection rate
Leimola-Virtanen et al[69]	Bs (TS)	Giemsa, ISH	RAS	Giemsa: 14/29 (50); ISH: 6/29 (20)
Porter et al[70]	BL (CCS)	Ser (ELISA)	75 RAS, 83 (15 other oral ulcerative disorders, 41 other oral mucosal lesions, 27 oral dysaesthesia), 25 control	23/75 (31) 27/83 (33) 6/25 (24)
Birek et al[71]	OS (CCS)	PCR (ureC)	RAS	23/32 (72)
Riggio et al[72]	Bs (CCS)	PCR (16S rRNA)	28 RAS, 20 OLP, 13 control	3/28 (11), 0/20 (0); 0/13 (0)
Shimoyama et al[73]	BL, OS (CCS)	MCT, Ser (ELISA)	RAS	0/12 (0)
Victória et al[74]	OS (CCS)	N-PCR1	36 RAS, 48 control	14/36 (38); 16/48 (33)
Iamaroon et al[75]	OS (CCS)	N-PCR (H. pyloriaA)	22 RAU, 15 control (Tg)	1/22 (5); 3/15 (20)
Elsheikh et al[76]	Bs (CCS)	PCR (16S rRNA)	58 RAS and Lymp 88 RAS, 20 control	39/58 (67); 9/88 (10); 0/20 (0)
Mansour-Ghanaei et al[77]	BL, OS (CCS)	Ser (ELISA), PCR1	RAS	H. pylori-IgG: 26/50 (52); PCR: 1/50 (2)
Albanidou-Farmaki et al[78]	Sal, BL, RUT (CSS)	Ser (ELISA), 13-UBT	RAS	34/48 (71)
Karaca et al[79]	Gastric Bs (CSS)	Giemsa (PTE)	RAS	20/23 (89); P < 0.05
Maleki et al[80]	RUT (CCS)	13-UBT	43 RAS, 44 control	16/43 (37); 14/44 (32); P = 0.597
Taş et al[81]	Gastric Bs, BL (CSS)	13-UBT (PTE)	MAL (vitamin B12)	Pre: 30/46 (65); post: 12/30 (40)

¹Data not shown. Helicobacter pylori: H. pylori; BL: Blood; Bs: Biopsy; CCS: Case-control study; CSS: Cross-sectional study; H. pylori-IgG: Presence of anti-H. pylori-IgG; ISH: In situ hybridization; Lymp: Lymphoma; MAL: Minor aphthous lesions; MCT: Microbial culture techniques; N: Nested; OLP: Oral lichen planus; OS: Oral swab; PCR: Polymerase chain reaction; PTE: Post-treatment evaluation; RAS: Recurrent aphthous stomatitis; RAU: Recurrent aphthous ulceration; RUT: Rapid urease test; Ser: Serology; Sal: Saliva; Tg: Tongue; TS: Transversal study;

¹³-UBT: ¹³C-urea breath test.