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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 7, 2014; 20(29): 9633-9652
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9633
Table 1 Boceprevir and telaprevir response guided therapy and futility rules
End-pointBoceprevirTelaprevir
RGTNon-cirrhotic treatment naïve patients, previously relapsers or partial respondersNon-cirrhotic treatment naïve patients previously relapsers
HCV-RNA undetectable at weeks 8 and 24HCV-RNA undetectable at weeks 4 and 24
Futility rulesHCV-RNA > 100 IU/mL at week 12HCV-RNA > 1000 IU/mL at weeks 4 and 12
HCV-RNA detectable at week 24HCV-RNA detectable at week 24