Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

doi:10.3748/wjg.v20.i29.10158

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2014; 20(29): 10158-10165
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10158

Table 5 Effects of methotrexate and antioxidant treatments on biochemical parameters of liver damage in serum

Groups	ALT(U/L)	AST(U/L)	ALP(U/L)	T. bilirubin(mg/dL)
Control	36 (34-48)	93.5 (74-135)	197 (168-271)	0.1 (0.1-0.2)
Model	119.5 (62-141)^a	49 (33-73)^a	102 (76-437)	0.1 (0.1-0.2)
MTX + NAC	107.5 (66-161)^b	50 (35-80)^b	84.5 (72-123)^a	0.1 (0.1-0.2)
MTX + AMF	74.5 (28-219)	31 (11-49)^a^c	57.5 (25-138)^a^e	0.1 (0.1-0.8)
MTX + ASC	91.5 (56-141)^b	45 (32-58)^a^d	87 (64-108)^a	0.15 (0.1-0.2)

Data are expressed median (range).

^aP = 0.001 vs control group;

^bP < 0.005 vs control group;

^cP < 0.05 vs model and MTX+NAC groups;

^dP < 0.05 vs MTX + AMF group;

^eP < 0.05 vs Model group. MTX: Methotrexate; NAC: N-acetyl cysteine; AMF: Amifostine; ASC: Ascorbic acid; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; T. bilirubin: Total bilirubin.

Citation: Akbulut S, Elbe H, Eris C, Dogan Z, Toprak G, Otan E, Erdemli E, Turkoz Y. Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World J Gastroenterol 2014; 20(29): 10158-10165
URL: https://www.wjgnet.com/1007-9327/full/v20/i29/10158.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i29.10158