Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

doi:10.3748/wjg.v20.i29.10158

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2014; 20(29): 10158-10165
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10158

Table 4 Effects of methotrexate and antioxidant treatments on oxidant-antioxidant parameters in serum

Groups	TAC(mmol/L)	TOS(mmol/L)	XO(U/g)
Control	1.3 (1.1-1.38)	13.05 (9.3-27.3)	2.41 (1.80-14.60)
Model	1.2 (0.9-1.5)	25.4 (16.1-49.7)^a	1.27 (0.56-17.35)^a
MTX + NAC	1.27 (1.15-1.4)	26.7 (18.5-62.2)^b	1.41 (0.68-2.75)^a
MTX + AMF	1.22 (0.3-1.4)	27.2 (10-61.2)	1.60 (0.41-2.29)^c
MTX + ASC	1.31 (0.95-1.44)	26.85 (12.2-97)^a	1.10 (0.24-1.48)^c^d

Data are expressed median (min-max).

^aP < 0.05 vs control group;

^bP = 0.005 vs control group;

^cP < 0.01 vs control group;

^dP < 0.05 vs MTX + AMF group. TAC: Total antioxidant capacity; TOS: Total oxidant status; XO: Xanthine oxidase; MTX: Methotrexate; AMF: Amifostine; NAC: N-acetyl cysteine; ASC: ascorbic acid.

Citation: Akbulut S, Elbe H, Eris C, Dogan Z, Toprak G, Otan E, Erdemli E, Turkoz Y. Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World J Gastroenterol 2014; 20(29): 10158-10165
URL: https://www.wjgnet.com/1007-9327/full/v20/i29/10158.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i29.10158