Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

doi:10.3748/wjg.v20.i29.10158

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2014; 20(29): 10158-10165
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10158

Table 3 Effects of methotrexate and antioxidant treatments on biochemical parameters of liver damage in liver tissues

Groups	MDA(nmol/g)	GSH(μmol/g)	SOD(U/g)	CAT(K/g)
Control	409 (352-466)	3.02 (2.85-3.43)	71.78 (61.88-97.81)	25.12 (21.08-29.28)
Model	455.5 (419-516)^a	2.52 (2.07-3.34)^a	61.46 (58.27-67.75)^a	23.89 (20.89-30.75)
MTX + NAC	436 (369-476)	3.22 (2.54-3.62)^b	69.22 (61.13-100.88)^c	22.16 (19.45-22.48)
MTX + AMF	442.5 (323-490)	2.92 (2.21-3.53)	63.78 (40.82-124.27)	20.88 (17.27-21.78)^d
MTX + ASC	420.5 (355-463)	2.84 (2.33-3.48)	61.81 (46.76-85.71)	21.51 (20.63-22.78)

Data are expressed median (range).

^aP < 0.05 vs control group;

^bP < 0.05 vs model group;

^cP < 0.01 vs model group;

^dP < 0.05 vs control vs model groups. MTX: Methotrexate; NAC: N-acetyl cysteine; AMF: Amifostine; ASC: Ascorbic acid; MDA: Malondialdehyde; GSH; Glutathione; SOD: Superoxide dismutase; CAT: Catalase.

Citation: Akbulut S, Elbe H, Eris C, Dogan Z, Toprak G, Otan E, Erdemli E, Turkoz Y. Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World J Gastroenterol 2014; 20(29): 10158-10165
URL: https://www.wjgnet.com/1007-9327/full/v20/i29/10158.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i29.10158