Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

doi:10.3748/wjg.v20.i29.10158

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

World J Gastroenterol. Aug 7, 2014; 20(29): 10158-10165
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10158

Table 2 Effects of methotrexate and antioxidant treatments on body weight

	Control	Model	MTX + NAC	MTX + AMF	MTX + ASC
BW	387 (301-332)	318 (246-292.5)^a	295 (226-272)^b	306 (183-282.5)^a	340 (249-274)^c

Data are expressed median (range).

^aP < 0.005 vs control group;

^bP = 0.001 vs control group;

^cP < 0.01 vs control group. MTX: Methotrexate; NAC: N-acetyl cysteine; AMF: Amifostine; BW: Body weight; ASC: Ascorbic acid.

Citation: Akbulut S, Elbe H, Eris C, Dogan Z, Toprak G, Otan E, Erdemli E, Turkoz Y. Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World J Gastroenterol 2014; 20(29): 10158-10165
URL: https://www.wjgnet.com/1007-9327/full/v20/i29/10158.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i29.10158