KISS1 methylation and expression as predictors of disease progression in colorectal cancer patients

Table 1 Relationships between KISS1 methylation and expression and clinicopathological characteristics in colorectal cancer patients

Clinicopathological traits		n	Methylated (n)	Rate	P value1	RQ3	P value2	Gray value4	P value2
Age (yr)	≤ 60	78	65	83.33%	0.602	0.445 ± 0.062	0.367	0.534 ± 0.047	0.136
	> 60	48	40	83.33%		0.359 ± 0.075		0.420 ± 0.059
Gender	Male	65	53	81.54%	0.577	0.345 ± 0.086	0.230	0.423 ± 0.047	0.071
	Female	61	52	85.25%		0.489 ± 0.083		0.560 ± 0.058
Location	Proximal	67	57	85.07%	0.576	0.453 ± 0.073	0.261	0.466 ± 0.051	0.544
	Distal	59	48	81.36%		0.388 ± 0.092		0.512 ± 0.055
Size (cm)	< 3	58	50	86.21%	0.424	0.442 ± 0.085	0.363	0.536 ± 0.049	0.130
	> 3	68	55	80.88%		0.343 ± 0.083		0.421 ± 0.056
Histology well		46	31	67.39%	0.001a	0.546 ± 0.095	0.016a	0.575 ± 0.078	0.134
Moderate, poor		80	74	92.50%		0.243 ± 0.085		0.451 ± 0.041
Depth of invasion	T1 + T2	44	27	61.35%	0.001a	0.963 ± 0.112	0.001a	0.875 ± 0.047	0.001a
	T3 + T4	82	78	95.12%		0.223 ± 0.054		0.341 ± 0.029
Lymph node metastasis	Yes	48	45	93.75%	0.014a	0.168 ± 0.058	0.001a	0.292 ± 0.034	0.001a
	No	78	60	76.92%		0.682 ± 0.105		0.631 ± 0.050
Distant metastasis	Yes	11	11	100.00%	0.019a	0.024 ± 0.012	0.001a	0.151 ± 0.031	0.014a
	No	115	94	81.74%		0.486 ± 0.089		0.512 ± 0.038

^aP < 0.05 vs relevant control group.

¹χ² test;

²Student’s t test; ^3,4mean ± SD.