Alterations in enterocyte mitochondrial respiratory function and enzyme activities in gastrointestinal dysfunction following brain injury

Figure 2 Activities of rat enterocyte mitochondrial related enzymes after traumatic brain injury. A: Pyruvate dehydrogenase (PDH) activity was significantly decreased at 6 h and continued up to 7 d after TBI compared with the control group (6 h: 90 ± 8, 12 h: 85 ± 10, 24 h: 65 ± 12, day 2: 60 ± 9, day 3: 55 ± 6, day 7: 88 ± 11). The minimum PDH activity was seen at day 3; B: The changes in α-ketoglutaric dehydrogenase (KGDH) activity were similar to those of PDH, except that the decrease in KGDH activity began at 12 h (12 h: 90 ± 12, 24 h: 80 ± 9, day 2: 76 ± 15, day 3: 68 ± 7, day 7: 90 ± 13); C: No significant change in malate dehydrogenase (MDH) activity was observed. ^bP < 0.01 vs control group.