Prognostic significance of nuclear hepatoma-derived growth factor expression in gallbladder cancer

Figure 1 Enhanced expression of hepatoma-derived growth factor in gallbladder cancer and its negative association with prognosis. A: Negative staining in normal glandular epithelium (× 200); B: Moderate staining predominantly localized in the cell nuclei in an adenocarcinoma. Arrows denote areas of positivity (× 200); C: Moderate to strong staining predominantly localized in the cell cytoplasm in an adenocarcinoma. Arrows denote areas of positivity (× 200); D: Average staining scores of nuclear hepatoma-derived growth factor (HDGF) expression in cholelithiasis and gallbladder cancer (GBC) tissues; E: Average staining scores of cytoplasmic HDGF expression in cholelithiasis and GBC tissues; F: Kaplan-Meier plots of overall survival in GBC patients with positive and negative HDGF expression scores.