Conventional, but not remote ischemic preconditioning, reduces iNOS transcription in liver ischemia/reperfusion

Figure 2 Inducible nitric oxide synthase or interleukin-1R mRNA in liver tissue (mean ± SE) in rats previously subjected to 60 min of ischemia/reperfusion injury after ischemic preconditioning or remote ischemic preconditioning. A: iNOS transcription. The iNOS transcription was significantly increased in the R-IPC group (n = 8) after 4 h of reperfusion compared with the IPC group (n = 8), ^aP < 0.05 vs IPC group; B: IL-1R transcription. The IL-1R transcription decreased in the IPC group during reperfusion (P = 0.027) but did not change in the R-IPC group. The transcription after ischemia was higher in the IPC group than in the R-IPC group; ^bP < 0.01, IPC group vs R-IPC group. iNOS: Inducible nitric oxide synthase; IL-1R: Interleukin-1R; IPC: Ischemic preconditioning; R-IPC: Remote ischemic preconditioning.