Down-regulation of FoxM1 inhibits viability and invasion of gallbladder carcinoma cells, partially dependent on inducement of cellular senescence

Figure 6 Down-regulation of Forkhead box M1 suppressed cell invasion and migration in gallbladder carcinoma-SD cells as measured by the Transwell cell coated or uncoated with growth factor-reduced Matrigel. Compared with the control group (A) and NC group (B), shF1822 (C) significantly inhibited the invasion ability of gallbladder carcinoma (GBC)-SD cells; D: Cells that invaded the bottom well were counted from 10 different visual fields. Compared with the control group (E) and NC group (F), shF1822 (G) significantly inhibited the migration ability of GBC-SD cells; H: Cells that invaded the bottom well were counted from 10 different visual fields. Data are mean ± SD from three independent experiments. ^aP < 0.05 vs control.