Polymorphisms in the IFNL3/IL28B gene and hepatitis C: From adults to children

Figure 1 Type III interferons bind to their receptor complexes and activate Janus kinase and protein tyrosine kinase 2, which leads to activation of the signal transducer and activator of transcription protein kinases. Activation of the JAK-STAT pathway leads, in turn, to the induction ISGs, which have immunomodulatory functions and are responsible for the antiviral activity of IFN-λs (see text for more details). IFNs: Interferons; JAK: Janus kinase; Tyk2: Tyrosine kinase 2; STAT PKs: Signal transducer and activator of transcription protein kinases; ISGs: IFN-stimulated genes.