Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier

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Jul 28, 2014 (publication date) through Feb 18, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2014; 20(28): 9468-9475
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9468

Table 1 Interaction of mucus and bacteria

Effect of mucus on bacteria	Effect of bacteria on mucus
Limits the direct contact between the host and bacteria	Maintenance of the mucus layer is stimulated by bacterial fermentation products
Serves as a source of nutrients for bacterial growth	Mediate the expression of MUC2
Contributes to the selection of the species-specific colon flora	Dissolve the protective inner mucus layer
Contains several proteins that limit bacterial growth and penetration

Citation: Chen SJ, Liu XW, Liu JP, Yang XY, Lu FG. Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier. World J Gastroenterol 2014; 20(28): 9468-9475
URL: https://www.wjgnet.com/1007-9327/full/v20/i28/9468.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i28.9468