Osteoporosis and fractures in liver disease: Relevance, pathogenesis and therapeutic implications

Table 1 Epidemiology of bone abnormalities in liver disease

1Prevalence of liver diseases[12]
Cirrhosis	0.10%
Non-alcoholic liver disease	2%-44%
Chronic hepatitis B between	0.1%-0.7%
Chronic hepatitis C	0.003%-4.5%
Autoimmune liver diseases	0.03%
Liver transplantations	5000/yr
Total	2.233%-49.36%
In patients with liver disease
Prevalence of osteoporosis[13,14]	1%-21%
Estimated prevalence	20-420 osteoporotic patients/2000 patients with liver disease/100000 persons
Fractures[13,14]	3%-44%
Estimated risk	60-880 osteoporotic patients/2000 patients with liver disease/100000 persons

¹The data on the prevalence of liver diseases are obtained from a study limited to Europe.