Neoadjuvant strategies for pancreatic cancer

doi:10.3748/wjg.v20.i28.9374

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jul 28, 2014; 20(28): 9374-9383
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9374

Table 3 Studies on neoadjuvant chemotherapy for locally advanced pancreatic cancer

Ref.	Study type	CT regimen	Staging system	LAPC (n)	Res rate (%)	R0 resections/total resections	ORR	OS median
Lee et al[51]	Prospective non-randomized	Gemcitabine + capecitabine	NCCNAPBCC	18 BR 25 UR33 BR 10 UR	61 BR 24 UR46 BR 20 UR	9/11 BR 5/6 UR13/15 BR 1/2 UR	NRNR	23.1 mo (cumulative)
Sahora et al[52]	Prospective phase II	NeoGEMTAX	NR	12 BR 13 UR	32	7/8	NR	16 mo (resected patients)
FARIS¹ et al[54]	Single centre, retrospective	FOLFIRINOX	NCNN	22	NR	22.7	27.3% (CT alone)	NR
Hosein¹ et al[39]	Prospective phase II	FOLFIRINOX	NR	14 BR 4UR	55.5	7/8	NR	16 mo (resected patients)

¹Some patients had CRT. ORR: Overall response rate; OS: Overall survival; NR: Not reported; NeoGEMTAX: Gemcitabine + docetaxel; FOLFIRINOX: 5-Fluorouracil + leucovorin + oxaliplatin + irinotecan; GEM: Gemcitabine; GEM FDR: Gemcitabine fixed dose ratio; NCCN: National comprehensive cancer network; APBCC: Asan pancreaticobiliary cancer center.

Citation: Polistina F, Natale GD, Bonciarelli G, Ambrosino G, Frego M. Neoadjuvant strategies for pancreatic cancer. World J Gastroenterol 2014; 20(28): 9374-9383
URL: https://www.wjgnet.com/1007-9327/full/v20/i28/9374.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i28.9374