Cytokinome profile evaluation in patients with hepatitis C virus infection

doi:10.3748/wjg.v20.i28.9261

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2014; 20(28): 9261-9269
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9261

Table 4 List of cytokines with significantly different serum levels between liver cirrhosis and hepatocellular carcinoma patients, and the pathways in which they play important roles

Ingenuity canonical pathways	Molecules
T helper cell differentiation	IL-18, IL-6R, IL-2RA
Role of macrophages, fibroblasts, and endothelial	IL16, IL-18, IL-6R, CXCL12
Hepatic fibrosis/hepatic stellate cell activation	LEP, HGF, IL-6R
Leptin signaling in obesity	LEP, GHRL
IL-6 Signaling	IL-18, IL-6R
AMPK Signaling	LEP, ADIPOQ
Hepatic cholestasis	IL-18, GCG
Acute phase response signaling	IL-18, IL-6R
Role of cytokines in mediating communication between immune cells	IL-18
IL-2 signaling	IL-2RA
ErbB2-ErbB3 signaling	ERBB2
Role of JAK1 and JAK3 in cytokine signaling	IL-2RA
Chemokine signaling	CXCL12
HGF Signaling	HGF
Type II diabetes mellitus signaling	ADIPOQ
p38 MAPK signaling	IL-18
LXR/RXR activation	IL-18
CXCR4 signaling	CXCL12
NF-κB signaling	IL-18

LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; HGF: Hepatocyte growth factor.

Citation: Capone F, Guerriero E, Colonna G, Maio P, Mangia A, Castello G, Costantini S. Cytokinome profile evaluation in patients with hepatitis C virus infection. World J Gastroenterol 2014; 20(28): 9261-9269
URL: https://www.wjgnet.com/1007-9327/full/v20/i28/9261.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i28.9261