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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 28, 2014; 20(28): 9253-9260
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9253
Table 1 Current stage of development of direct antiviral agents
Inhibitors of the NS3/4A serine protease
First-generation
BoceprevirApproved
TelaprevirApproved
FaldaprevirActive clinical development
SovaprevirActive clinical development
AsunaprevirActive clinical development
SimeprevirActive clinical development
DanoprevirActive clinical development
VaniprevirActive clinical development
Second-generation
MK-5172Active clinical development
NS5A inhibitors
DaclatasvirAdvanced clinical development
GS-5885Active clinical development
ABT-267Active clinical development
PPI-461Active clinical development
MK-8762Active clinical development
NS5B polymerase inhibitors
Nucleos(t)ide inhibitors
SofosbuvirAdvanced clinical development
MericitabineActive clinical development
ALS-2200Active clinical development
Non-nucleos(t)ide inhibitors
SetrobuvirActive clinical development
ABT-333Active clinical development
GSK625433Active clinical development