Polymorphisms in the IFNL3/IL28B gene and hepatitis C: From adults to children

Table 2 Paediatric studies exploring the association between single nucleotide polymorphisms in the interferon L3 gene and treatment-induced clearance of hepatitis C virus

Ref.	Number of children enrolled	SNPs evaluated	Summary of the results
Hierro et al[39]	69	rs12979860 rs8099917	The CC genotype of rs12979860 and the T/T genotype of rs8099917 were associated with treatment-induced (IFN monotherapy and Peg-IFN-α and ribavirin association) clearance of HCV (viral genotype data not provided)
Domagalski et al[40]	82	rs12979860rs8099917rs12980275	The CC genotype of rs12979860 and the T/T genotype of rs8099917 were associated with treatment-induced (Peg-IFN-α and ribavirin association) clearance of HCV (viral genotypes 1 and 4; OR = 6.81; 95%CI: 1.98-23.42; P = 0.001 and OR = 3.14; 95%CI: 1.26-7.85; P = 0.013, respectively)
			The rs12980275 SNP was not associated with virological response.
Komatsu et al[41]	63	rs8099917	The rs8099917 SNP was not associated with treatment-induced (response-guided IFN monotherapy and/or Peg-IFN-α and ribavirin association) clearance of HCV (viral genotypes 1, 2, 3 and 4)
Shaker et al[42]	34	rs12979860	The CC genotype of rs12979860 was associated with treatment-induced (Peg-IFN-α and ribavirin association) clearance of HCV (viral genotype 4)
			OR = 2.45; 95%CI not reported; P = 0.02

SNPs: Single nucleotide polymorphisms; HCV: Hepatitis C virus; IFN: Interferon.