Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers

Table 1 Representative primary androgen-responsive genes and androgen-responsive genes lacking genomic androgen response elements, previously reported in hepatocllular carcinoma and/or pancreatic cancer

ARGs[24]	Signal pathways1	Reported diseases
Primary ARGs
CYR61	Wnt/β-catenin	HCC, pancreatic cancer
SNAI2	Epithelial-mesenchymal transition (EMT)	HCC, pancreatic cancer
FN1	Cell surface and extracellular matrix	HCC
ATP1A1	Na,K-ATPase pump	Pancreatic cancer
FKBP5	AKT	Pancreatic cancer
VEGFA	Angiogenesis	HCC, pancreatic cancer
SGK	Serine/threonine kinase	HCC, pancreatic cancer
SLC22A3	Organic cation transporter	HCC, pancreatic cancer
NDRG1	P53/N-myc	HCC, pancreatic cancer
NFKBIA	NF-κB inhibitory family	HCC
PYGB	Glycogen catabolism	HCC, pancreatic cancer
ARGs lacking AREs
ADAMTS1	Inflammatory process	HCC, pancreatic cancer
CXCR7	Orphan G-protein coupled receptor	HCC, pancreatic cancer
GATA2	Transcription factor	Pancreatic cancer
MYC	Oncogene	HCC, pancreatic cancer
KLF4	Cell proliferation	HCC, pancreatic cancer

¹Genes were annotated in accordance with NCBI and Reference[24]. CYR61: Cystein-rich, angiogenic inducer, 61; SNAI2: Snail family zinc finger 2; FN1: Fibronectin 1; ATP1A1: ATPase, Na+/K+ transporting, alpha 1 polypeptide; FKBP5: FK506 binding protein 5; VEGFA: Vascular endothelial growth factor A; SGK: Serum/glucocorticoid regulated kinase 1; SLC22A3: Solute carrier family 22, member 3; NDRG1: N-myc downstream regulated 1; NFKBIA: Nuclear factor kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; PYGB: Phosphorylase, glycogen, brain; ADAMTS1: ADAM metallopeptidaas with thrombospondin type 1 motif, 1; CXCR7: Chemokine (C-X-C motif) receptor 7; GATA2: GATA binding protein 2; MYC: V-myc avian myelocytomatosis viral oncogene homolog; KLF4: Kruppel-like factor 4 (gut); ARE: Androgen responsive element.