Mast cell deficiency exacerbates inflammatory bowel symptoms in interleukin-10-deficient mice

Figure 1 Mast cell deficiency aggravated colitis in the colon of interleukin-10-deficient mice. A: Pathological score; B: mRNA expression of inflammatory cytokines; C: Relative IL-1β protein content; D: NF-κB p65 inflammatory signaling; E: Relative myeloperoxidase content in colonic tissue; F: Goblet cell density. Mean ± SE, ^aP < 0.05, DKO vs IL-10-deficient, ^bP < 0.01, DKO vs IL-10-deficient, n = 8 for mRNA analysis, n = 10 for others. IL: Interleukin; DKO: Double knockout; MPO: Myeloperoxidase; NF-κB: Nuclear factor κB.