Role of Notch signaling pathway in gastric cancer: A meta-analysis of the literature

Table 3 Meta-analysis of other components of Notch signaling pathway and gastric cancer

Stratification of gastric cancer	Notch2		Notch3		Jagged1		Jagged2		DLL4		Hes1
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Tumor tissue vs normal tissue	292.00 (23.75-3589.39)	< 0.01a	-	-	0.94 (0.00-254.96)	0.98	-	-	3.84 (2.52-5.83)	< 0.01a	14.31 (4.11-49.87)	< 0.01a
Gender:	-	-	1.01 (0.46-2.26)	0.97	1.26 (0.36-4.39)	0.36	2.90 (0.76-11.02)	0.12	1.03 (0.57-1.86)	0.93	1.05 (0.47-2.35)	0.90
Male vs female
Age (yr):	-	-	0.75 (0.30-1.88)	0.54	1.19 (0.48-2.94)	0.70	0.17 (0.02-1.40)	0.10	0.52 (0.13-2.16)	0.37	1.13 (0.45-2.81)	0.80
≤ 55 vs > 55
Location:	-	-	-	-	0.63 (0.26-1.50)	0.30	-	-	-	-	-	-
Cardia vs noncardia
Lauren's classification:	0.60 (0.02-15.19)	0.76	2.61 (1.17-5.84)	0.02a	2.02 (1.11-3.69)	0.02a	3.97 (1.17-13.46)	0.03a	-	-	1.71 (0.88-3.30)	0.11
Intestinal vs diffuse
Histological differentiation:	-	-	2.04 (0.89-4.67)	0.09	2.18 (1.23-3.86)	< 0.0a	1.36 (0.44-4.18)	0.60	0.89 (0.52-1.54)	0.69	1.78 (0.95-3.34)	0.07
Well/moderate vs poor/undifferentiated
T stage:	-	-	2.40 (0.73-7.92)	0.15	0.50 (0.03-8.54)	0.63	3.70 (1.05-13.08)	0.04a (T1 vs T2-4)	0.29 (0.16-0.54)	< 0.01a	1.72 (0.49-6.00)	0.39 (T1 vs T2-4)
T1-2 vs T3-4
N stage:	-	-	1.84 (0.71-4.75)	0.21	0.82 (0.44-1.50)	0.51	0.91 (0.23- 3.55)	0.89	0.12 (0.06-0.23)	< 0.01a	0.39 (0.04-4.38)	0.45
N0 vs N1-3
Distal metastasis:	-	-	-	-	-	-	-	-	0.55 (0.10-3.00)	0.49	1.76 (0.36-8.51)	0.48
Negative vs positive
TNM stage:	-	-	1.19 (0.54-2.63)	0.67	0.78 (0.42-1.42)	0.41	1.32 (0.44-3.98)	0.62	0.15 (0.03-0.80)	0.03a	0.70 (0.15-3.36)	0.66
Stages I-II vs III-IV

^aP < 0.05. DLL: Delta-like; TNM: Tumor node metastasis.