Role of Notch signaling pathway in gastric cancer: A meta-analysis of the literature

doi:10.3748/wjg.v20.i27.9191

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World Journal of Gastroenterology

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Meta-Analysis

World J Gastroenterol. Jul 21, 2014; 20(27): 9191-9199
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.9191

Table 2 Meta-analysis of Notch1 and gastric cancer

Stratification of gastric cancer	No. of participants	OR (95%CI)	Statistical method	P value	Ref.
Gender:	1040	1.21 (0.92-1.59)	Fixed	0.18	9[8-11,15,17-20]
Male vs female	1040	1.21 (0.92-1.59)	Fixed	0.18	9[8-11,15,17-20]
Age (yr):	607	1.36 (0.96-1.91)	Fixed	0.08	4[8,10,11,19]
≤ 60 vs > 60	607	1.36 (0.96-1.91)	Fixed	0.08	4[8,10,11,19]
Location:	589	0.62 (0.43-0.91)	Fixed	0.01^a	5[8,11,17,19,20]
Cardia vs noncardia	589	0.62 (0.43-0.91)	Fixed	0.01^a	5[8,11,17,19,20]
Tumor size:	634	0.68 (0.49-0.94)	Fixed	0.02^a	5[8,11,15,19,20]
≤ 5 cm vs > 5 cm	634	0.68 (0.49-0.94)	Fixed	0.02^a	5[8,11,15,19,20]
Lauren's classification:	680	1.45 (1.03-2.03)	Fixed	0.03^a	5[9,11,13,15,17]
Intestinal vs diffuse	680	1.45 (1.03-2.03)	Fixed	0.03^a	5[9,11,13,15,17]
Histological differentiation:	1220	1.42 (0.85-2.37)	Random	0.17	11[7-11,14,15,17-20]
Well/moderate vs poor/undifferentiated	1220	1.42 (0.85-2.37)	Random	0.17	11[7-11,14,15,17-20]
Lymphovascular invasion:	258	0.49 (0.28-0.87)	Fixed	0.01^a	2[10,17]
Negative vs positive	258	0.49 (0.28-0.87)	Fixed	0.01^a	2[10,17]
T stage:	453	0.71 (0.24-2.09)	Random	0.54	5[7,10,14,18,20]
T1-2 vs T3-4	453	0.71 (0.24-2.09)	Random	0.54	5[7,10,14,18,20]
N stage:	1220	1.07 (0.57-2.00)	Random	0.83	11[7-11,14,15,17-20]
N0 vs N1-3	1220	1.07 (0.57-2.00)	Random	0.83	11[7-11,14,15,17-20]
Distal metastasis:	285	0.33 (0.14-0.78)	Fixed	0.01^a	3[10,14,18]
Negative vs positive	285	0.33 (0.14-0.78)	Fixed	0.01^a	3[10,14,18]
TNM stage:	567	0.91 (0.53-1.57)	Random	0.74	7[8,9,14,15,17-19]
Stages I-II vs III-IV	567	0.91 (0.53-1.57)	Random	0.74	7[8,9,14,15,17-19]

^aP < 0.05. TNM: Tumor node metastasis.

Citation: Du X, Cheng Z, Wang YH, Guo ZH, Zhang SQ, Hu JK, Zhou ZG. Role of Notch signaling pathway in gastric cancer: A meta-analysis of the literature. World J Gastroenterol 2014; 20(27): 9191-9199
URL: https://www.wjgnet.com/1007-9327/full/v20/i27/9191.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i27.9191