Role of liver biopsy in nonalcoholic fatty liver disease

Table 1 Brunt grading system

Grade	Steatosis	Ballooning	Inflammation
Mild (1)	1-2 (< 66%)	Minimal	L: 1-2 P: 0-1
Moderate (2)	2-3	Present-zone 3	L: 2 P: 1-2
Severe (3)	2-3	Marked-zone 3	L: 3 P: 1-2

Reproduced with permission[101]. Steatosis: grade 1: < 33%; grade 2: > 33%-66%; grade 3: > 66%. Lobular inflammation: grade 1: < 2 foci per 200 × field; grade 2: 2-4 foci per 200 × field; grade 3: > 4 foci per 200 × field. Portal inflammation: grade 0: None; grade 1: Mild; grade 2: Moderate; grade 3: Severe. Ballooning: grade 1: Rare; grade 2: Prominent ballooning. L: Lobular/acinar inflammation; P: Portal inflammation.