Breath volatile organic compounds for the gut-fatty liver axis: Promise, peril, and path forward

Table 3 Breath research often failed to meet its potential for multiple reasons

Technical/scientific factors
Monitor/interface/biology	Too many interrelated unknowns
Unique data: uncertain utility	Relevance difficult to establish
	Relevance may not exist
Non-technical factors
Inadequate teams	Engineers, chemists, doctors, statisticians
Inadequate synergy	Single center efforts
Lack of focus	Too many diseases, too little strategy
Lack of common languages	Device development is not drug development
Few models of commercial success	Difficult to envision endgame