Molecular biomarkers for the detection of metastatic colorectal cancer cells

doi:10.3748/wjg.v20.i27.8928

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2014; 20(27): 8928-8938
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8928

Table 1 Sensitivities and specificities of various studies that took blood samples n (%)

Source	Method	Marker	Sensitivity	Specificity	Ref.
Serum	MSP	CDKN2A (p16)	14/52 (27)	44/44 (100)	[32]
Serum	RT-PCR	CEA	51/121 (42)	27/33 (82)	[56]
Serum	RT-PCR	CK20	22/99 (22)	150/150 (100)	[38]
Serum	qPCR	miR-92	80/90 (89)	35/50 (70)	[84]
Serum	CellSearch	EpCAM	20/74 (27)	228/246 (93)	[88]
Serum	CLIA	CEA	188/429 (44)	184/201 (92)	[112]

MSP: Methylation-specific polymerase chain reaction; qPCR: Quantitative reverse transcription polymerase chain reaction (RT-PCR); CLIA: Chemiluminescence immunoassay; CEA: Carcinoembryonic antigen; CK20: Cytokeratin 20; EpCAM: Epithelial cell adhesion molecule.

Citation: Kamiyama H, Noda H, Konishi F, Rikiyama T. Molecular biomarkers for the detection of metastatic colorectal cancer cells. World J Gastroenterol 2014; 20(27): 8928-8938
URL: https://www.wjgnet.com/1007-9327/full/v20/i27/8928.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i27.8928