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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 21, 2014; 20(27): 8790-8795
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8790
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.8790
Table 3 Classification of the drugs concerning the fetal risk according to Food and Drug Administration
| Drugs | Recommendation |
| Adalimumab | Pregnancy (low risk) |
| Category B | Breastfeeding (probably compatible) |
| Azathioprine/6-mercaptopurina | Pregnancy (low risk) when used in low doses and as mono-therapy |
| Category D | Breastfeeding (it is recommended to breastfeed 4 h after taking the drug) |
| Balsalazide | Pregnancy (low risk) |
| Category B | Breastfeeding (probably compatible) |
| Certolizumab | Pregnancy (low risk) |
| Category B | Breastfeeding ( probably compatible) |
| Ciprofloxacin | Pregnancy (not recommended due to skeletal muscular dysfunction) |
| Category C | Breastfeeding (compatible) |
| Corticosteroids | Pregnancy (risk of adrenal insufficiency, premature rupture of membrane, in the first trimester although there is little risk of cleft palate) |
| Category C | Breastfeeding (probably compatible) |
| Cyclosporine | Pregnancy (no congenital abnormalities have been noticed) |
| Category C | Breastfeeding (contraindicated) |
| Infliximab | Gestation (low risk when administered as mono-therapy) (increased risk of infection when used in combination with azathioprine) |
| Category B | Breastfeeding (probably compatible) |
| Mezalazine | Pregnancy (asacol showed low risk of teratogenicity in animal models) |
| Category B | Breastfeeding (both probably compatible) |
| Asacol (category C) | |
| Methotrexate | Contraindicated in both conditions |
| Category X | |
| Metronidazole | Pregnancy (used in the first trimester increases the risk of cleft palate) |
| Category B | Breastfeeding (toxic) |
| Olsalazine category (C) | Pregnancy (limited risk) |
| Breastfeeding (probably compatible) | |
| Rifaximin | Pregnancy (animal studies show teratogenicity) |
| Category C | Lactation (its safety is unknown) |
| Sulfasalazine | Pregnancy (low risk if administered in conjunction with folic acid) |
| Category B | Breastfeeding (probably compatible) |
| Tacrolimus | Pregnancy (no increased risk described) |
| Category C | Breastfeeding (contraindicated) |
| Thalidomide | Contraindicated in both conditions |
| Category X |
- Citation: Cury DB, Moss AC. Treatment of Crohn’s disease in pregnant women: Drug and multidisciplinary approaches. World J Gastroenterol 2014; 20(27): 8790-8795
- URL: https://www.wjgnet.com/1007-9327/full/v20/i27/8790.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i27.8790