Clobenpropit enhances anti-tumor effect of gemcitabine in pancreatic cancer

Figure 6 Enhanced apoptosis of pancreatic cancer cells by gemcitabine and clobenpropit combination treatment. Clobenpropit enhanced apoptotic cell death in combination of gemcitabine in human pancreatic cancer cells. The percentage of apoptotic cells was determined by fluorescein isothiocyanate-labeled annexin V assay followed by flow cytometry. Statistically significant differences (^aP < 0.05 vs control group) of the combination treatment of gemcitabine (5 μmol/L) and clobenpropit (50 μmol/L) compared with control in Panc-1 (A), MiaPaCa-2 (B) and AsPC-1 (C). G: Gemcitabine; C: Clobenpropit.