High fat diet feeding results in gender specific steatohepatitis and inflammasome activation

Figure 2 High fat diet results in insulin resistance in male mice after 16 wk high fat diet feeding. Male and female mice were fed with either high fat diet (HFD) or chow diet for 6 or 16 wk. Glucose tolerance test (GTT) was performed: glucose levels were measured 0, 30, 75, 120 and 180 min after ip glucose injection in male (A) and female mice (B) fed with HFD for 16 wk. Insulin tolerance test (ITT) was performed: glucose levels were measured 0, 30, 75 and 120 min after ip insulin injection in male and female mice fed with HFD for 6 wk (C and D, respectively) or 16 wk (E and F, respectively). ^aP < 0.05, ^bP < 0.01 vs chow fed controls, n = 5/group, P = 0.03 vs chow fed controls in GTT-males, 16 wk, n = 5/group.