Liver zonation: Novel aspects of its regulation and its impact on homeostasis

Figure 2 Scheme illustrating aspects of zonation of central metabolism in normal mice. Selected functions of central metabolism are depicted as conical boxes showing the direction of their porto-central gradients with specific emphasis of the strength of this gradient in the glutamine synthetase-positive zone (right of the vertical line). Dashed boxes indicate gradients that have been determined using a single method only (proteome analysis), instead of at least two independent methods (other boxes). Since the data is valid for normal mice, the presumably corresponding gradient of Wnt/β-catenin signalling is depicted at the top of the scheme, above the row of the hepatocytes. PP: Periportal; PC: Pericentral.