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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 14, 2014; 20(26): 8458-8470
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8458
Figure 1
Figure 1 The mesenchymal-epithelial transition factor receptor functions as a transmembrane tyrosine kinase receptor. Ligand binding from hepatocyte growth factor (HGF)/scatter factor induces receptor dimerization and autophosphorylation of intracellular tyrosine residues, which serves as a catalytic site for the SH2 domains of numerous cytosolic signaling proteins. MET: Mesenchymal-epithelial transition factor.