APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans

Table 6 Distribution of genotypes and odds ratios for colorectal cancer stratified by body mass index

	< 25 kg/m2			≥25 kg/m2			P interaction
	Case/control	OR (95%CI)1	P value	Case/control	OR (95%CI)1	P value
OGG1 Ser326Cys							0.706
Ser/Ser	9/8	1.000		35/40	1.000
Ser/Cys	17/26	0.529 (0.149-1.880)	0.325	94/113	0.973 (0.567-1.668)	0.920
Cys/Cys	20/24	0.936 (0.269-3.258)	0.917	72/89	0.938 (0.536-1.643)	0.823
XRCC1 Arg399Gln							0.755
Arg/Arg + Gln/Gln	27/32	1.000		129/136	1.000
Arg/Gln	19/26	0.928 (0.396-2.175)	0.863	72/106	0.754 (0.510-1.114)	0.156
APE1 Asp148Glu							0.725
Asp/Asp	17/22	1.000		70/100	1.000
Asp/Glu	13/25	0.609 (0.222-1.674)	0.337	77/112	1.023 (0.666-1.571)	0.919
Glu/Glu	16/11	1.770 (0.594-5.274)	0.305	54/30	2.581 (1.489-4.474)	0.001
APE1 -141T/G							0.044
TT	17/9	1.000		76/84	1.000
TG	15/33	0.214 (0.069-0.660)	0.007	87/107	0.934 (0.608-1.434)	0.754
GG	14/16	0.406 (0.122-1.352)	0.142	38/51	0.860 (0.506-1.462)	0.577

¹Adjusted for age, gender, smoking status, body mass index, and family history of cancer. OGG1: 8-oxoguanine DNA-glycosylase 1; APE1: Apurinic endonuclease 1; XRCC1: X-ray repair cross-complementing protein 1.