APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans

Table 5 Distribution of genotypes and odds ratios for colorectal cancer stratified by alcohol consumption

	Non-drinkers			Drinkers			P interaction
	Case/control	OR (95%CI)1	P value	Case/control	OR (95%CI)1	P value
OGG1 Ser326Cys							0.068
Ser/Ser	33/32	1.000		11/16	1.000
Ser/Cys	87/98	0.888 (0.500-1.576)	0.684	24/41	0.793 (0.296-2.119)	0.643
Cys/Cys	56/80	0.728 (0.397-1.332)	0.303	36/33	1.806 (0.685-4.760)	0.232
XRCC1 Arg399Gln							0.174
Arg/Arg + Gln/Gln	106/121	1.000		50/47	1.000
Arg/Gln	70/89	0.909 (0.600-1.376)	0.651	21/43	0.327 (0.158-0.673)	0.002
APE1 Asp148Glu							0.848
Asp/Asp	62/89	1.000		25/33	1.000
Asp/Glu	64/92	1.043 (0.656-1.660)	0.857	26/45	0.816 (0.379-1.756)	0.603
Glu/Glu	50/29	2.654 (1.489-4.730)	0.001	20/12	2.095 (0.819-5.360)	0.123
APE1 -141T/G							0.618
TT	68/63	1.000		25/30	1.000
TG	72/98	0.651 (0.405-1.045)	0.076	30/42	0.805 (0.374-1.734)	0.580
GG	36/49	0.612 (0.346-1.082)	0.091	16/18	0.912 (0.366-2.270)	0.842

¹Adjusted for age, gender, smoking status, body mass index, and family history of cancer. OGG1: 8-oxoguanine DNA-glycosylase 1; APE1: Apurinic endonuclease 1; XRCC1: X-ray repair cross-complementing protein 1.