APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans

Table 4 Distribution of genotypes and odds ratios for colorectal cancer stratified by smoking status

	Non-smokers			Smokers			P interaction
	Case/control	OR (95%CI)1	P value	Case/control	OR (95%CI)1	P value
OGG1 Ser326Cys							0.432
Ser/Ser	30/32	1.000		14/16	1.000
Ser/Cys	75/86	0.921 (0.505-1.679)	0.788	36/53	0.753 (0.315-1.798)	0.523
Cys/Cys	54/72	0.850 (0.454-1.593)	0.613	38/41	1.087 (0.452-2.612)	0.853
XRCC1 Arg399Gln							0.003
Arg/Arg + Gln/Gln	93/118	1.000		63/50	1.000
Arg/Gln	66/72	1.120 (0.720-1.743)	0.614	25/60	0.289 (0.152-0.548)	< 0.001
APE1 Asp148Glu							0.706
Asp/Asp	58/80	1.000		29/42	1.000
Asp/Glu	60/84	1.089 (0.669-1.772)	0.733	30/53	0.867 (0.433-1.735)	0.687
Glu/Glu	41/26	2.356 (1.273-4.360)	0.006	29/15	3.299 (1.428-7.623)	0.005
APE1 -141T/G							0.858
TT	59/55	1.000		34/38	1.000
TG	66/91	0.668 (0.404-1.107)	0.118	36/49	0.796 (0.406-1.562)	0.507
GG	34/44	0.659 (0.361-1.201)	0.173	18/23	0.794 (0.352-1.791)	0.794

¹Adjusted for age, gender, alcohol consumption, body mass index, and family history of cancer. OGG1: 8-oxoguanine DNA-glycosylase 1; APE1: Apurinic endonuclease 1; XRCC1: X-ray repair cross-complementing protein 1.