APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans

Table 3 Gene distributions n (%)

Genes			Cases (n = 247)	Controls (n = 300)	Crude OR (95%CI)1	P value1	Adjusted OR (95%CI)2	P value2
OGG1	Genotype	Ser/Ser	44 (17.81)	48 (16.00)	1.000		1.000
Ser326Cys		Ser/Cys	111 (44.94)	139 (46.33)	0.871 (0.540-1.407)	0.572	0.862 (0.532-1.395)	0.546
		Cys/Cys	92 (37.25)	113 (37.67)	0.888 (0.542-1.454)	0.637	0.914 (0.556-1.502)	0.723
	Allele	Ser	199 (40.28)	235 (39.17)	1.000
		Cys	295 (59.72)	365 (60.83)	0.954 (0.748-1.217)	0.707
XRCC1	Genotype	Arg/Arg	131 (53.04)	142 (47.33)	1.000		1.000
Gln399Arg		Arg/Gln	91 (36.84)	132 (44.00)	0.747 (0.523-1.068)	0.110	0.744 (0.519-1.066)	0.107
		Gln/Gln	25 (10.12)	26 (8.67)	1.042 (0.573-1.896)	0.892	1.055 (0.577-1.930)	0.862
	Allele	Arg	353 (71.46)	416 (69.33)	1.000
		Gln	141 (28.54)	184 (30.67)	0.903 (0.695-1.173)	0.444
APE1	Genotype	Asp/Asp	87 (35.22)	122 (40.66)	1.000		1.000
Asp148Glu		Asp/Glu	90 (36.44)	137 (45.67)	0.921 (0.628-1.351)	0.674	0.939 (0.639-1.379)	0.747
		Glu/Glu	70 (28.34)	41 (13.67)	2.394 (1.491-3.844)	< 0.001	2.411 (1.497-3.886)	< 0.001
	Allele	Asp	264 (53.44)	381 (63.50)	1.000
		Glu	230 (46.56)	219 (36.50)	1.516 (1.189-1.932)	0.001
APE1 promoter	Genotype	TT	93 (37.65)	93 (31.00)	1.000		1.000
-141T/G		TG	102 (41.30)	140 (46.67)	0.729 (0.496-1.070)	0.106	0.748 (0.508-1.104)	0.144
		GG	52 (21.05)	67 (22.33)	0.776 (0.489-1.232)	0.282	0.781 (0.490-1.247)	0.301
	Allele	T	288 (58.30)	326 (54.33)	1.000
		G	206 (41.70)	274 (45.67)	0.851 (0.669-1.082)	0.188

¹Obtained by χ² test, and the significance level was adjusted to 0.0125;

²Adjusted with age, gender, smoking status, alcohol consumption, body mass index, and family history of cancer. OGG1: 8-oxoguanine DNA-glycosylase 1; APE1: Apurinic endonuclease 1; XRCC1: X-ray repair cross-complementing protein 1.