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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Jul 14, 2014; 20(26): 8681-8690
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8681
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8681
Normal liver (n = 35) | End-stage livers (n = 93) | |||||
Gene | Expression% | -fold | mean ± SE | Expression% | -fold | mean ± SE |
AhR | 5.52-27.1 | 4.91 | 14.7 ± 0.74 | 2.71-128 | 47.2 | 17.4 ± 1.52 |
CYP1A2 | 20.5-537 | 26.2 | 234 ± 94.6 | 0.78-175 | 224 | 136 ± 23.9a |
CAR | 0.55-14.1 | 25.6 | 7.87 ± 0.50 | 0.21-293 | 1395 | 7.73 ± 0.86 |
CYP2B6 | 1.31-102 | 77.9 | 17.1 ± 2.74 | 0.81-128 | 158 | 27.2 ± 2.77a |
CYP2C9 | 14.4-1544 | 107 | 786 ± 57.9 | 3.74-1486 | 387 | 418 ± 34.8a |
CYP2C19 | 49.6-1254 | 25.2 | 594 ± 40.2 | 1.75-1379 | 788 | 256 ± 23.9a |
CYP2D6 | 10.7-316 | 29.5 | 149 ± 12.2 | 4.31-930 | 216 | 156 ± 15.6 |
CYP2E1 | 210-3577 | 17.2 | 1708 ± 115 | 17.7-4373 | 247 | 990 ± 75.4a |
PXR | 14.2-189 | 13.3 | 41.4 ± 4.95 | 3.01-87.1 | 29.0 | 33.0 ± 1.81 |
CYP3A4 | 171-1357 | 7.94 | 798 ± 49.2 | 8.21-1966 | 240 | 498 ± 48.6a |
CYP3A5 | 22.2-659 | 30.0 | 278 ± 26.9 | 9.92-979 | 98.7 | 203 ± 19.1a |
CYP3A7 | 86.3-1054 | 12.2 | 450 ± 36.7 | 1.51-2137 | 1415 | 479 ± 47.7 |
PPARα | 13.7-57.7 | 4.21 | 29.4 ± 1.89 | 2.61-169 | 64.8 | 27.6 ± 2.43 |
CYP4A11 | 15.1-478 | 31.6 | 198 ± 17.2 | 1.41-740 | 524 | 89.2 ± 11.1a |
- Citation: Chen H, Shen ZY, Xu W, Fan TY, Li J, Lu YF, Cheng ML, Liu J. Expression of P450 and nuclear receptors in normal and end-stage Chinese livers. World J Gastroenterol 2014; 20(26): 8681-8690
- URL: https://www.wjgnet.com/1007-9327/full/v20/i26/8681.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i26.8681