Pro-atherosclerotic markers and cardiovascular risk factors one year after liver transplantation

doi:10.3748/wjg.v20.i26.8667

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jul 14, 2014; 20(26): 8667-8673
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8667

Table 4 Comparison among liver transplant recipients, non-alcoholic steatohepatitis and controls regarding endothelial biomarkers

Variable (pg/mL)	NASH (n = 22)	LTR (n = 44)	Controls (n = 10)	P³
sVCAM-1¹	1692.4 ± 457.4	1820.6 ± 443.9	1167.2 ± 121.8	< 0.001
sICAM-1¹	259.7 ± 101	230.3 ± 96.3	152.9 ± 33.9	0.015
MPO¹	198.3 ± 116.2	93.7 ± 60.9	409.2 ± 204.9	< 0.001
Adiponectin¹	23789.1 ± 12040.4	47965.3 ± 33140.8	32683.2 ± 25065.4	0.008
PAI-1¹	149.2 ± 63.1	40.4 ± 28.7	132.3 ± 58.4	< 0.001
SAP¹	59031.5 ± 17024.2	29174.5 ± 20175.2	40452.8 ± 18557.44	< 0.001
SAA²	21303 (8723.6-30583.2)	5390.9 (2567.4-18562.04)	9008.6 (3230.7-13977.4)	< 0.001
E-selectin²	90.03 (69.5-137.1)	48.5 (36.04-70.9)	35.7 (28.4-47.04)	< 0.001
MMP-9²	289.3 (107.6-410.4)	50.5 (35.2-99.5)	411.5 (241.2-587.4)	0.002
HsCRP²	1.78 (0.70-3.51)	0.53 (0.21-1.13)	0.29 (0.16-0.55)	0.009

¹Mean ± SD;

²Median (25^th-75^th percentiles); ³Comparisons: sVCAM-1 (LTR = NASH - P = 0.5; LTR > controls - P < 0.001); s-ICAM-1 (LTR = NASH - P = 0.48; LTR > controls - P = 0.05; MPO (LTR < NASH - P = 0.02; LTR < controls - P < 0.001); Adiponectin (LTR > NASH - P = 0.007; LTR = controls - P = 0.27); PAI-1 (LTR < NASH and controls - P < 0.001); SAP (LTR < NASH - P < 0.001; LTR = controls - P = 0.22); SAA (LTR < NASH - P = 0.006; LTR = controls - P = 0.91); E-selectin (LTR < NASH - P = 0.001; LTR > controls - P = 0.04); MMP-9 (LTR < NASH and controls - P < 0.001); CRP (LTR < NASH - P = 0.007; LTR = controls - P = 0.41). sVCAM-1: Soluble vascular cell adhesion molecule-1; sICAM-1: Soluble intracellular cell adhesion molecule-1; PAI-1: Plasminogen activator inhibitor 1; SAP: Serum amyloid P; SAA: Serum amyloid A; MMP-9: Matrix metallopeptidase 9; HsCRP: High-sensitivity C-reactive protein; LTR: Liver transplant recipients; NASH: Non-alcoholic steatohepatitis.

Citation: Alvares-da-Silva MR, Oliveira CPMS, Stefano JT, Barbeiro HV, Barbeiro D, Soriano FG, Farias AQ, Carrilho FJ, D’Albuquerque LAC. Pro-atherosclerotic markers and cardiovascular risk factors one year after liver transplantation. World J Gastroenterol 2014; 20(26): 8667-8673
URL: https://www.wjgnet.com/1007-9327/full/v20/i26/8667.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i26.8667