Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans

doi:10.3748/wjg.v20.i26.8592

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2014; 20(26): 8592-8598
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8592

Table 3 Codominant model odds ratios of the PRKAA1 polymorphisms for gastric cancer

SNPs		Adjusted OR (95%CI)	Pvalue¹	Q²
rs6882903	CC	1.00	0.0123	0.0123
	CA	1.46 (1.07-2.00)
	AA	1.75 (0.60-5.08)

rs10074991	AA	1.00	0.0005	0.0023
	AG	1.30 (0.90-1.87)
	GG	2.15 (1.40-3.30)

rs13361707	TT	1.00	0.0009	0.0023
	TC	1.29 (0.90-1.85)
	CC	2.05 (1.35-3.14)

rs154268	TT	1.00	0.0017	0.0028
	TC	1.63 (1.20-2.22)
	CC	1.77 (0.82-3.83)

rs3805486	TT	1.00	0.0099	0.0123
	TC	0.72 (0.40-1.32)
	CC	0.54 (0.30-0.98)
VEGAS statistics (P)		46.0927 (0.0004)

¹P values for logistic analysis of codominant model adjusted with age, sex, calorie intake, smoking history, alcohol intake and educational level; ²False discovery rate Q value. SNP: Single nucleotide polymorphism; VEGAS: Versatile gene-based association study.

Citation: Kim YD, Yim DH, Eom SY, Moon SI, Yun HY, Song YJ, Youn SJ, Hyun T, Park JS, Kim BS, Lee JY, Won HK, Kim H. Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans. World J Gastroenterol 2014; 20(26): 8592-8598
URL: https://www.wjgnet.com/1007-9327/full/v20/i26/8592.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i26.8592