Prognostic significance of preoperative fibrinogen in patients with colon cancer

Table 2 Univariate survival analyses of clinicopathological parameters

Parameters	n	5-yr DFS	χ2	Pvalue	5-yr OS	χ2	Pvalue
Age (yr)
< 60	119	49.3%	0.301	0.583	64.90%	0.616	0.432
≥ 60	136	47.7%			61.80%
Nationality
Han	216	51.3%	3.185	0.203	64.60%	3.477	0.176
Uygur	30	34.4%			48.80%
Others	9	33.3%			76.20%
BMI (kg/m2)
< 18.5	8	37.5%	3.905	0.272	50%	9.296	0.026
18.5-23.99	115	46.5%			55.60%
24-27.99	102	54.4%			74.00%
≥ 28	30	39.7%			59.30%
Smoking
Never	173	49.1%	0.079	0.961	65.00%	0.153	0.927
Light	18	50.0%			60.20%
Heavy	64	47.7%			61.40%
Grade
Low	203	52.7%	5.948	0.015	67.10%	4.482	0.034
High	52	32.7%			49.30%
TNM
I	29	78.7%	38.724	0.000	86.20%	28.420	0.000
II	139	57.3%			70.60%
III	87	25.2%			43.90%
Type
Mess type	104	54.3%	2.523	0.283	68%	3.088	0.213
Ulceration	148	44.1%			59.30%
Infiltrative	3	27.2%			0
Tumor location
Left	155	51.8%	2.992	0.224	67.20%	5.563	0.062
Right	89	42.0%			54.30%
Transverse	11	54.5%			81.80%
Perineural invasion
Yes	7	42.9%	0.551	0.458	42.90%	2.108	0.147
No	248	48.6%			63.90%
Vascular invasion
Yes	13	15.4%	8.432	0.004	30.80%	7.747	0.005
No	242	50.3%			65.10%
CEA (ng/mL)
< 5	161	56.6%	18.630	0.000	71.20%	15.269	0.000
≥ 5	94	33.6%			49.10%
AFP (ng/mL)
< 5	231	49.7%	3.568	0.059	65.20%	5.117	0.024
≥ 5	24	35.0%			43.20%
mGPS
0	163	58.9%	79.236	0.000	77.80%	90.552	0.000
1	71	60.2%			49.80%
2	21	0.0%			4.80%
WBC count
< 5 × 109/L	61	60.9%	4.032	0.045	76.70%	4.870	0.027
≥ 5 × 109/L	194	44.8%			59.30%
NLR
< 5	238	50.1%	6.060	0.014	64.70%	4.754	0.029
≥ 5	17	25.0%			43.80%
PLR
< 150	134	55.6%	11.095	0.004	71.20%	11.772	0.003
150-300	105	43.0%			57.20%
> 300	15	20.0%			33.30%
Fibrinogen (g/L)
< 2.61	74	77.0%	26.717	0.000	87.20%	20.255	0.000
≥ 2.61	181	36.9%			53.60%

DFS: Disease-free survival; OS: Overall survival; BMI: Body mass index; TNM: Tumor-node-metastasis; CEA: Carcinoembryonic antigen; AFP: Alpha-fetoprotein; mGPS: Modified Glasgow prognostic scores; WBC: White blood cell; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet-lymphocyte ratio.