Changes in circulating Foxp3+ regulatory T cells and interleukin-17-producing T helper cells during HBV-related acute-on-chronic liver failure

Table 3 Correlations between clinical characteristics and host immune data during the onset, peak, and recovery phases of hepatitis B virus-related acute-on-chronic liver failure

		Onset								Peak								Recovery
		Th17		Treg		Treg/Th17		IL-17		Th17		Treg		Treg/Th17		IL-17		Th17		Treg		Treg/Th17		IL-17
		r	P-value	r	P-value	r	P-value	r	P-value	r	P-value	r	P-value	r	P-value	r	P-value	r	P-value	r	P-value	r	P-value	r	P-value
Total patients	ALT	0.17	0.49	-0.02	0.92	-0.004	0.98	-0.17	0.48	-0.20	0.44	0.11	0.68	0.42	0.10	-0.56	0.02	-0.17	0.56	-0.33	0.24	0.00	1.00	-0.24	0.41
	TBIL	0.06	0.81	-0.21	0.38	-0.20	0.41	-0.28	0.25	0.04	0.88	-0.11	0.68	-0.04	0.88	-0.30	0.23	-0.30	0.29	-0.15	0.59	-0.09	0.76	-0.36	0.19
	MELD-Na	0.09	0.71	-0.02	0.91	-0.18	0.46	-0.01	0.96	0.02	0.95	-0.09	0.74	0.07	0.79	-0.06	0.82	-0.50	0.06	-0.01	0.98	0.15	0.60	-0.27	0.34
Survivors	ALT	-0.11	0.71	0.17	0.56	0.25	0.40	-0.12	0.68	-0.42	0.15	0.12	0.73	0.58	0.04	-0.53	0.06	-0.19	0.52	-0.17	0.57	0.19	0.53	-0.29	0.32
	TBIL	-0.17	0.57	0.09	0.75	0.14	0.63	-0.33	0.26	-0.29	0.34	-0.34	0.25	0.01	0.99	-0.14	0.65	-0.35	0.23	0.05	0.85	0.06	0.83	-0.42	0.14
	MELD-Na	-0.54	0.05	0.008	0.98	0.30	0.32	0.01	0.96	-0.08	0.80	-0.33	0.27	-0.10	0.75	0.24	0.44	-0.55	0.05	0.18	0.54	0.31	0.29	-0.32	0.27

ALT: Alanine aminotransferase; TBIL: Total bilirubin; PTA: Prothrombin activity; MELD-Na: Model for end-stage liver diseases and sodium; Th17: Interleukin-17-producing T helper cells; Treg: Foxp3⁺ regulatory T cell; Treg/Th17: Ratio of Treg to Th17 cells. Data were analyzed by Spearman correlation test.