Novel diagnostics for aggravating pancreatic fistulas at the acute phase after pancreatectomy

Table 3 Diagnostic value of clinical factors for clinically relevant postoperative pancreatic fistula

Variable	Univariate			Multivariable
	Odds ratio	95%CI	P value	Odds ratio	95%CI	P value
Age (≥ 65 yr)	1.16	0.61-2.23	0.654
Gender (male)	1.29	0.66-2.53	0.459
Diabetes mellitus	1.39	0.67-2.92	0.378
History of pancreatitis	0.62	0.23-1.59	0.321
Body mass index (≥ 22)	1.48	0.79-2.82	0.226
Operative procedure (DP)	1.65	0.83-3.28	0.151
Invasive carcinoma of the pancreas	2.31	1.21-4.47	0.011	2.94	1.08-8.55	0.035
Operative time (≥ 360 min)	1.33	0.71-2.53	0.376
Blood loss (≥ 600 mL)	1.83	0.97-3.51	0.063	1.73	0.62-4.86	0.297
Intraoperative transfusion	1.45	0.48-4.59	0.511
Pancreas texture (soft)	1.46	0.69-3.10	0.322
Main pancreatic duct (< 4 mm)	1.36	0.70-2.65	0.366
Persistence of high fever (≥ 38 °C, ≥ 3 d)	1.10	0.57-2.14	0.781
Persistence of SIRS (≥ 3 d)	1.68	0.88-3.23	0.116
Usage of catecholamines	1.73	0.68-4.62	0.251
Total lymphocyte count (< 600/mm3, POD 3)	1.73	0.74-4.23	0.201
Platelet count (< 164000/mm3, POD 3)	2.28	1.20-4.39	0.012	1.28	0.44-3.64	0.646
CRP (≥ 158 mg/L, POD 3)	4.82	2.37-10.2	< 0.001	2.39	0.73-8.03	0.150
Neutrophil-to-lymphocyte ratio (≥ 9.6, POD 3)	1.84	0.97-3.52	0.061	1.56	0.55-4.40	0.401
CRP elevation (≥ 28.4 mg/L, POD 1 to 3)	11.4	4.35-34.3	< 0.001	4.82	1.25-20.2	0.022
Drain amylase (≥ 1918 IU/mL, POD 3)	3.00	1.57-5.86	0.001	1.50	0.55-4.08	0.423
Drain fluid bacterial culture (positive, POD 3)	1.62	0.68-3.87	0.278

Analyzed by binomial logistic analyses. DP: Distal pancreatectomy; SIRS: Systemic inflammatory response syndrome; CRP: C-reactive protein; POD: Postoperative day.