Novel diagnostics for aggravating pancreatic fistulas at the acute phase after pancreatectomy

Table 2 Inflammatory markers for clinically relevant postoperative pancreatic fistulas

Marker	POD 1		POD 3			POD 5		Change from POD 1 to 3			Change from POD 3 to 5
	AUC	P value	AUC	P value	Cutoff	AUC	P value	AUC	P value	Cutoff	AUC	P value
White blood cell count (/mm3)	0.545	0.343	0.524	0.615	11400	0.588	0.067	0.504	0.939	600	0.557	0.242
Neutrophil count (/mm3)	0.560	0.198	0.532	0.495	8200	0.591	0.060	0.506	0.898	-3300	0.560	0.215
Total lymphocyte count (/mm3)	0.524	0.604	0.577	0.097	600	0.541	0.397	0.550	0.285	0	0.518	0.708
Platelet count (/mm3)	0.540	0.399	0.615	0.014	164000	0.580	0.098	0.603	0.028	-24000	0.549	0.310
Serum amylase (IU/mL)	0.504	0.935	0.580	0.087	136	0.600	0.039	0.502	0.966	-69	0.522	0.643
C-reactive protein (mg/L)	0.534	0.532	0.688	< 0.001	158	0.684	< 0.001	0.767	< 0.001	28.4	0.565	0.200
Procalcitonin (ng/mL)	-	-	0.584	0.451	0.3	-	-	-	-	-	-	-
Neutrophil-to-lymphocyte ratio	0.532	0.497	0.579	0.092	9.6	0.590	0.061	0.537	0.433	-0.3	0.558	0.420
Platelet to lymphocyte ratio	0.517	0.718	0.529	0.557	231	0.557	0.243	0.508	0.858	67	0.539	0.231

P values were of the comparison between grade A and grade B/C as calculated by the Mann–Whitney U test. Cutoff values were determined by receiver operating characteristic curve analyses. POD: Postoperative day; AUC: Area under the curve.