Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment

Table 1 Studies with histopathological evaluation of diabetic patients with non-alcoholic fatty liver disease

Ref.	Sample size	Metabolic syndrome and its components	Diabetes duration (yr)	Diabetes-related complications	Elevated enzyme levels AST/ALT/GGT	Risk factors for NASH	Fibrosis
Amarapurka et al[12]	36						30.5%
Gupte et al[13]	32				ALT and/or AST 31%	No risk factors	22%
Kemmer et al[38]	22 (females)					No risk factors
Leite et al[6]	92	Hypertension 88%	7.8	Microvascular 46%	14%/16%/13%	Hypertriglyceridemia High ALT	34%-60%
		Dyslipidaemia 86%		Macrovaascular 26%		Low HDL-chol
Prashanth et al[5]	83	Metabolic syndrome 77%	8.2		ALT 7%	MS components	37%
						High ALT
						High AP

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gammaglutamyltransferase; AP: Alkaline phosphatase; NASH: Non-alcoholic steatohepatitis; HDL-chol: HDL-cholesterol.