Inhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin

Figure 2 Effect of Girdin on DLD1 sensitivity to oxaliplatin. A: Quantification of Girdin mRNA by real-time polymerase chain reaction to validate knockdown effect of four siRNA duplexes targeting Girdin; B: Girdin mRNA level in DLD1 cells after infection with a lentivirus expressing an shRNA targeting Girdin; C: Detection of Girdin and TOP2B proteins by Western blotting; D: Growth inhibition of DLD1 cells by oxaliplatin in combination with knockdown of Girdin. ^aP < 0.05 vs scramble shRNA.