Effect of a high-fat diet in development of colonic adenoma in an animal model

Figure 2 Changes in body weight and representative images of the liver. A: Changes in body weight of rats fed a normal-fat diet (ND) (blue line, n = 10) and high-fat diet (HFD) (red line, n = 10). Significant differences were observed between the ND and HFD groups at all time points except for the initial 2 wk; B: Representative images of the liver from the ND group (left) and HFD group (right). The liver from the HFD group appeared to have a fatty liver-like appearance, and the Oil Red O staining also present that there are more lipid droplets in the cytoplasm of liver cells. Imaging was documented at × 200 magnification; C: Average weight of the liver from the two groups. Each column represents the mean ± SD of 10 rats/group; D: Average weight of epididymal fat from the two groups. Each column represents the mean ± SD of 10 rats/group. ^aP < 0.01, ND vs HFD; E: Average number of adenomas for rats fed an ND and HFD.